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TREASURE HUNT- LOOKING FOR HIDDEN SOURCES
Gap
Incomplete work up stroke patients leads to an increased risk of recurrent stroke.
Need
Aggressive evaluation including TEE, prolonged cardiac monitoring and hematologic workup
Can lead to improved clinical outcomes.
Objective
In patients presenting with stroke, diagnostic evaluation generally includes anatomic imaging of the brain, and a review of blood pressure control and imaging of cerebral and carotid arteries. Additional diagnosis entities to consider include paroxysmal atrial fibrillation with concomitant left atrial appendage thrombus,patent foramen ovale and paradoxic embolism, mitral stenosis, endocarditis and aortic atherosclerotic disease. Management strategies can be divided into two broad areas that includes antiplatelet and anticoagulation therapies as well mechanical approaches using disc occluders for patent foramen ovale and Watchman devices for occlusion of the left atrial appendage.Current guidelines for the use of these devices as well as outcome data will be presented. Controversies in the use of anticoagulant drugs will be discussed with an emphasis on the concept of bridging therapies during anticoagulant interruption.
THE FORGOTTEN RIGHT HEART
Gap
Common diseases of the right heart remain an area fraught with difficulties in diagnosis and management.. Failure to discover pulmonary hypertension and pulmonary emboli leads to a reduction in quality of life and poor clinical outcomes. Evolving use of catheter directed thrombolysis may lead to improved clinical outcomes in patients with submassive and massive pulmonary emboli. Diagnostic and therapeutic treatments of this class remains under utilized.
Need
Foremost is the need to include pulmonary hypertension and acute and chronic pulmonary emboli in the differential diagnosis of patients presenting with shortness of breath. Non invasive and invasive diagnostic techniques need to be more commonly utilized to document pulmonary hypertension. Catheter based thrombolytic therapy is now available in our community and adds a potential life saving approach.
Objectives
Right heart catheterization remains an important tool for evaluation of symptomatic patients suspected of having pulmonary hypertension. Evaluation for chronic thromboembolic pulmonary hypertension, left heart failure, mitral valve disease and primary pulmonary hypertension now leads to improved clinical outcomes. Use of endothelial receptor antagonists, prostanoids and phosphodiesterase 5 inhibitors represent effective tools in management of severe pulmonary hypertension. On the acute side of right heart disease, acute pulmonary emboli are estimated to cause 250 000 cases of sudden death each year. Directed thrombolytic therapy offers an opportunity to reduce complications from systemic therapy as well as reducing long term right heart failure.
OLD VALVES- NEW TREATMENTS
Gap
Many patients with severe aortic and mitral valve disease were previously thought not to be candidates for repair. Technological advances now allow for non-surgical repair with reasonable morbidity and mortality. Treatment of these lesions remains underutilized.
Need
Symptomatic patients with severe aortic stenosis previously considered to be surgically inoperable may now be offered trans aortic valve replacement (TAVR) as an excellent option to improve quality of life and survival. In a similar argument, symptomatic patients with severe degenerative mitral regurgitation who were previously thought to be high risk surgical candidates may now be offered mitral clip procedures.
Objectives
Key to management of mitral regurgitation involves precise evaluation of the severity and etiology of mitral valve disease. Transesophogeal echo and 3D imaging are comprehensive studies which are important in determining optimal candidates for both surgical and catheter based mitral valve repair. Information gained is also important in guiding adequate repairs. Management of mitral regurgitation centers on issues of medical optimization of coexisting conditions as well as timing of surgical repair. Selection of appropriate candidates for open surgical repair and replacement focuses on the realization that early treatment of mitral regurgitation prevents irreversible systolic dysfunction and heart failure. Advantages of mitral valve repair include freedom from tissue prosthesis degeneration and the lack of requirement for anticoagulation with mechanical devices. Mitral clip procedures offer an opportunity for palliation of severe mitral insufficiency without the need for median sternotomy and cardiopulmonary bypass. Severe aortic stenosis is increasingly recognized in our aging population. TAVR offers shorter hospital stays with comparable outcomes in selected patients and is now being performed on an increasing basis.
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